The positive likelihood ratio for having coronary artery disease if nitroglycerin relieved chest pain was 1.1 (0.96-1.34). The diagnostic sensitivity of nitroglycerin to determine cardiac chest pain was 72% (64%-80%), and the specificity was 37% (34%-41%). Nitroglycerin relieved chest pain in 66% of the subjects. Patients with acute myocardial infarction diagnosed after obtaining an ECG, patients whose chest pain could not be quantified, those for whom no cardiac work-up was done, or those who received emergent cardiac catheterization.Ģ70 patients were enrolled. Prospective observational cohort study with a 4-week follow-up of patients enrolled.Īcademic tertiary care hospital, with 60,000 visits/year.Īdult patients presenting to the emergency department with active chest pain who received nitroglycerin and were admitted for chest pain. To determine if relief of chest pain with nitroglycerin can be used as a diagnostic test to help differentiate cardiac chest pain and non-cardiac chest pain. It is often believed that chest pain relieved by nitroglycerin is indicative of coronary artery disease origin.
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